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ABSTRACT
The aim of the study was to assess
the ileal function in 79 patients (9 controls, 5 after ileal resections,
4 after radiation therapy, 6 Crohn's disease, 19 primary bile acid
malabsorption, 7 giardiasis pre and post therapy, 3 blind loop syndromes,
7 postcholecystectomy diarrhoeic syndromes and 4 cholecystectomy
without diarrhoea, 5 iritabile bowel syndromes and 10 different
diarrhoeic syndromes). After orally administration of 0.37MBq SeHCAT
its abdominal retention was measured by uncolimated gama camera,
after 3h, 4 and 7 days. Retention curves showed monoexponential
decline and were fitted well by function y=e.
The values of 7
day abdominal retention of SeHCAT are dIvided into two groups. In
first of them was control patientes as well as patientes with blind
loop syndroma, cholecystectomy without diarrhoea, iritabile bowel
syndroma and giardiasis post therapy and their values of 7
day abdominal retention of SeHCAT was in physiological limits. The
second group included patients after ileal resections, radiation
therapy, Crohn's disease, primary bile acid malabsorption, giardiasis
pretherapy, postcholecystectomy syndroma with diarrhoea and different
diarrhoeic syndromas with low values of 7
day abdominal retention of SeHCAT. Although the method does not
differentiate causes of malabsorption, its clinical benefit is to
prove the bile acid malabsorption, which could be treated by specific
cholestiramine therapy. SeHCAT test is non-invasive, high sensitive
in vivo test of ileal function.
Key words: SeHCAT, ileal function assessment, primary bile acid malabsorption
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