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ABSTRACT
Prostate specific antigen (PSA) is the most important of all tumor markers beacause it has significant applications in all aspects of the management of men with prostatic disease. This article reviews the salient features of PSA, with particular emphasis on the strategies used to improve its utility in the diagnosis of prostate cancer. With recognition of molecular forms of PSA, however, the ratio of free to total PSA, and now the complex form of PSA, have been shown to be more specific indicators of the presence of malignancy.
The discovery of PSA and development of assay to measure it will be undoubtedly recorded as one of the most important advances in the management of men with prostate cancer.
Key words : PSA, diagnosis, prostate cancer
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